' 
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Maitake Mushroom Extract standardized to 30% pure D-fraction (9 mg)
30 mg
**
Cat's Claw Extract (bark) standardized to 4% alkaloids (0.4 mg)
10 mg
**
Top Medical Research Studies
8
Maitake-polysaccharide enhances apoptosis
Induction Effect to Apoptosis by Maitake Polysaccharide: Synergistic Effect of Its Combination With Vitamin C in Neuroglioma Cell.
Combination treatment complicates effects.
We set out to understand how maitake mushroom polysaccharide (MP), when combined with vitamin C (VC), affects brain tumor cells, specifically in human neuroglioma M059 K cells. Through our study, we found that using a combination of MP and VC led to a significant reduction in cell viability—about 53.10%. This indicates that these compounds together may weaken the tumor cells' ability to survive.
Our findings also showed that this combination treatment caused cell cycle arrest at the G2/M phase, meaning that it effectively stopped the cells from proceeding through their natural life cycle. Notably, we observed that 38.54% of the treated cells went through apoptosis, a form of programmed cell death critical for eliminating cancerous cells.
We noted changes in proteins associated with apoptosis, showing upregulation of Bax and caspase-3, while Bcl-2 levels decreased. Additionally, there was an increase in the activities of caspase-3, caspase-8, and caspase-9. These observations suggest that the anticancer effects we witnessed likely stem from the induction of apoptosis triggered by the combined treatment of MP and VC.
Our findings also showed that this combination treatment caused cell cycle arrest at the G2/M phase, meaning that it effectively stopped the cells from proceeding through their natural life cycle. Notably, we observed that 38.54% of the treated cells went through apoptosis, a form of programmed cell death critical for eliminating cancerous cells.
We noted changes in proteins associated with apoptosis, showing upregulation of Bax and caspase-3, while Bcl-2 levels decreased. Additionally, there was an increase in the activities of caspase-3, caspase-8, and caspase-9. These observations suggest that the anticancer effects we witnessed likely stem from the induction of apoptosis triggered by the combined treatment of MP and VC.
Read More
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Evaluates inositol's therapeutic potential
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
8.8
Improved condition
I purchased this for my elderly dog, who I suspect has a brain tumour. After suffering from epilepsy and being unable to move, she experienced incontinence. This treatment has made her feel much better after a week, and for over half a month she has been like her old self again. I recommend taking one tablet in the morning and evening for treatment, and one tablet each time for maintenance.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
- All Researches
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Evaluates inositol's therapeutic potential
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
8
Maitake-polysaccharide enhances apoptosis
Induction Effect to Apoptosis by Maitake Polysaccharide: Synergistic Effect of Its Combination With Vitamin C in Neuroglioma Cell.
Combination treatment complicates effects.
We set out to understand how maitake mushroom polysaccharide (MP), when combined with vitamin C (VC), affects brain tumor cells, specifically in human neuroglioma M059 K cells. Through our study, we found that using a combination of MP and VC led to a significant reduction in cell viability—about 53.10%. This indicates that these compounds together may weaken the tumor cells' ability to survive.
Our findings also showed that this combination treatment caused cell cycle arrest at the G2/M phase, meaning that it effectively stopped the cells from proceeding through their natural life cycle. Notably, we observed that 38.54% of the treated cells went through apoptosis, a form of programmed cell death critical for eliminating cancerous cells.
We noted changes in proteins associated with apoptosis, showing upregulation of Bax and caspase-3, while Bcl-2 levels decreased. Additionally, there was an increase in the activities of caspase-3, caspase-8, and caspase-9. These observations suggest that the anticancer effects we witnessed likely stem from the induction of apoptosis triggered by the combined treatment of MP and VC.
Our findings also showed that this combination treatment caused cell cycle arrest at the G2/M phase, meaning that it effectively stopped the cells from proceeding through their natural life cycle. Notably, we observed that 38.54% of the treated cells went through apoptosis, a form of programmed cell death critical for eliminating cancerous cells.
We noted changes in proteins associated with apoptosis, showing upregulation of Bax and caspase-3, while Bcl-2 levels decreased. Additionally, there was an increase in the activities of caspase-3, caspase-8, and caspase-9. These observations suggest that the anticancer effects we witnessed likely stem from the induction of apoptosis triggered by the combined treatment of MP and VC.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved condition
I purchased this for my elderly dog, who I suspect has a brain tumour. After suffering from epilepsy and being unable to move, she experienced incontinence. This treatment has made her feel much better after a week, and for over half a month she has been like her old self again. I recommend taking one tablet in the morning and evening for treatment, and one tablet each time for maintenance.
Read More
